Pyruvate kinase deficiency is a rare, hereditary, chronic condition that is associated with hemolytic anemia. In a phase 2 study, mitapivat, an oral, first-in-class activator of erythrocyte pyruvate ...
Pyruvate kinase occupies a central role in glycolysis, catalysing the conversion of phosphoenolpyruvate to pyruvate with concomitant ATP generation. Its activity is finely tuned by allosteric ...
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